Structure of PDB 5dlg Chain A Binding Site BS02

Receptor Information
>5dlg Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5dlg Lesion Orientation ofO4-Alkylthymidine Influences Replication by Human DNA Polymeraseeta.
Resolution2.351 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 K43 G46 S62 M63 W64 K86 R93 K311 P316 K317 T318 G320 S322 K323 N324 P326
Binding residue
(residue number reindexed from 1)		Q41 Y42 W45 K46 G49 S65 M66 W67 K89 R96 K309 P314 K315 T316 G318 S320 K321 N322 P324
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5dlg, PDBe:5dlg, PDBj:5dlg
PDBsum5dlg
PubMed27574558
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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