Structure of PDB 5di3 Chain A Binding Site BS02

Receptor Information

>5di3 Chain A (length=164) Species: 3055 (Chlamydomonas reinhardtii)

EARILVLGLDNAGKTTILKALSEEDITTITPTQGFNIKSLSRDGFNLKIW
DIGGQKSIRPYWRNYFDQTDALIYVIDSADSKRLSESEFELTELLQEEKM
TGVPLLVFANKQDLVGALAADEIASTLDLTSIRDRPWQIQACSAKQGTGL
KEGMEWMMKQVKLE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5di3 Chain A Residue 202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5di3 A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): T30 T47
• Binding residue (residue number reindexed from 1): T15 T32
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D85
• Catalytic site (residue number reindexed from 1): D70

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding

Biological Process

• GO:0015031 protein transport
• GO:0051301 cell division

Cellular Component

• GO:0000139 Golgi membrane
• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005794 Golgi apparatus
• GO:0005815 microtubule organizing center
• GO:0005819 spindle
• GO:0005856 cytoskeleton
• GO:0016020 membrane

External links

• PDB: RCSB:5di3, PDBe:5di3, PDBj:5di3
• PDBsum: 5di3
• PubMed: 26551564
• UniProt: A8ISN6|ARL3_CHLRE ADP-ribosylation factor-like protein 3 (Gene Name=ARL3)