Structure of PDB 5df6 Chain A Binding Site BS02
Receptor Information
>5df6 Chain A (length=212) Species:
9606
(Homo sapiens) [
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RRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTH
IKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLN
CADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRT
GDDKGESKSKVTHVMIRCQKYDVGGGERFDSLTDLVEHYKKNPMVETLGT
VLQLKQPLNTTR
Ligand information
>5df6 Chain C (length=12) Species:
9606
(Homo sapiens) [
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KFMPPPTYTEVD
Receptor-Ligand Complex Structure
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PDB
5df6
Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
Resolution
1.78 Å
Binding residue
(original residue number in PDB)
K120 R138 Q141 S142 V148 T168 H169 M171 M202 V203 T205
Binding residue
(residue number reindexed from 1)
K117 R135 Q138 S139 V145 T162 H163 M165 M194 V195 T197
Enzymatic activity
Enzyme Commision number
3.1.3.48
: protein-tyrosine-phosphatase.
External links
PDB
RCSB:5df6
,
PDBe:5df6
,
PDBj:5df6
PDBsum
5df6
PubMed
26527736
UniProt
Q06124
|PTN11_HUMAN Tyrosine-protein phosphatase non-receptor type 11 (Gene Name=PTPN11)
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