Structure of PDB 5d9y Chain A Binding Site BS02

Receptor Information
>5d9y Chain A (length=413) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCRCVEQIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVI
YTGKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILIL
VWEGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETC
GASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLST
LMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHA
HRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGS
VEAQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCGSDEVWSDSEQSFLDPD
IGGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMN
EPKHGLALWEAKM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5d9y Structural insight into substrate preference for TET-mediated oxidation.
Resolution1.971 Å
Binding residue
(original residue number in PDB)		M1293 Y1294 N1296
Binding residue
(residue number reindexed from 1)		M162 Y163 N165
Binding affinityPDBbind-CN: Kd=0.9uM
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0070579 5-methylcytosine dioxygenase activity
Biological Process
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5d9y, PDBe:5d9y, PDBj:5d9y
PDBsum5d9y
PubMed26524525
UniProtQ6N021|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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