Structure of PDB 5d0i Chain A Binding Site BS02

Receptor Information
>5d0i Chain A (length=62) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTIERFTFPHKYKDEKCTICLSMLEDGEDVRRLPCMHLFHQLCVDQWLAM
SKKCPICRVDIE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5d0i Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5d0i Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		C294 C297 H317 C320
Binding residue
(residue number reindexed from 1)		C17 C20 H40 C43
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5d0i, PDBe:5d0i, PDBj:5d0i
PDBsum5d0i
PubMed26656854
UniProtQ6ZSG1|ARK2C_HUMAN E3 ubiquitin-protein ligase ARK2C (Gene Name=ARK2C)

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