Structure of PDB 5czv Chain A Binding Site BS02

Receptor Information

>5czv Chain A (length=225) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNS
RCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNT
EECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILR
TSLRFRLDAHGQAMVFPYHIGSVVMLEIDNRLCLQSPENDHCFPDAQSAA
DYLGALSAVERLDFPYPLRDVRGEP

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

5czv Chain A Residue 5002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5czv Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.
Resolution	3.19 Å
Binding residue (original residue number in PDB)	L1436 N1439 R1441 D1443 D1454
Binding residue (residue number reindexed from 1)	L46 N49 R51 D53 D64
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0038023	signaling receptor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0007219	Notch signaling pathway
GO:0007275	multicellular organism development
GO:0030154	cell differentiation

	Cellular Component
GO:0016020	membrane

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Cellular Component

External links

PDB	RCSB:5czv, PDBe:5czv, PDBj:5czv
PDBsum	5czv
PubMed	27157619
UniProt	Q9UM47\|NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (Gene Name=NOTCH3)

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