Structure of PDB 5cr0 Chain A Binding Site BS02

Receptor Information
>5cr0 Chain A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKH
YSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVD
VAITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRL
PGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSE
HALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB5cr0 Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
Resolution2.75 Å
Binding residue
(original residue number in PDB)		Q372 S463 Q464 R514 R517 A518 K521 E529
Binding residue
(residue number reindexed from 1)		Q43 S134 Q135 R185 R188 A189 K192 E200
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D98 D100 D161
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5cr0, PDBe:5cr0, PDBj:5cr0
PDBsum5cr0
PubMed26836966
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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