Structure of PDB 5cg8 Chain A Binding Site BS02
Receptor Information
>5cg8 Chain A (length=266) Species:
5762
(Naegleria gruberi) [
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MINKKSLLQNLLSKCKTTFQQSFTNANITLKDEKWLKNVRTAYFVCDHDG
SVELAYLPNVLPKELVEEFTEKFESIQTGRKKDTGYSGILDNSMPFNYVT
ADLSQELGQYLSEIVNPQINYYISKLLTCVSSRTINYLVSLNDSYYALNN
CLYPSTAFNSLKPSNDGHRIRKPHKDNLDITPSSLFYFGNFQNTEGYLEL
TDKNCKVFVQPGDVLFFKGNEYKHVVANITSGWRIGLVYFAHKGSKTKPY
YEDTQKNSLKIHKETK
Ligand information
>5cg8 Chain C (length=14) [
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tggaacggaattct
Receptor-Ligand Complex Structure
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PDB
5cg8
Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA.
Resolution
2.702 Å
Binding residue
(original residue number in PDB)
Y141 Y153 T155 A156 R224 D234 V293 F295 H297 Q310 K311
Binding residue
(residue number reindexed from 1)
Y86 Y98 T100 A101 R169 D179 V238 F240 H242 Q255 K256
Enzymatic activity
Enzyme Commision number
1.14.11.80
: methylcytosine dioxygenase.
External links
PDB
RCSB:5cg8
,
PDBe:5cg8
,
PDBj:5cg8
PDBsum
5cg8
PubMed
26323320
UniProt
D2W6T1
|TET1_NAEGR Tet-like dioxygenase 1 (Gene Name=TET1)
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