Structure of PDB 5btr Chain A Binding Site BS02

Receptor Information

>5btr Chain A (length=370) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETI
PPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLT
GAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFF
KFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPE
IVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVP
QILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNPVKLSEI
TEQYLFLPPNRYIFHGAEVY

Ligand information

>5btr Chain E (length=4) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RHKA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5btr Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
Resolution	3.2 Å
Binding residue (original residue number in PDB)	F148 D150 P180
Binding residue (residue number reindexed from 1)	F5 D7 P20

Enzymatic activity

Catalytic site (original residue number in PDB)	P271 D272 F273 R274 N346 D348 H363
Catalytic site (residue number reindexed from 1)	P111 D112 F113 R114 N186 D188 H203
Enzyme Commision number	2.3.1.- 2.3.1.286: protein acetyllysine N-acetyltransferase.

Gene Ontology

	Molecular Function
GO:0070403	NAD+ binding

View graph for
Molecular Function

External links

PDB	RCSB:5btr, PDBe:5btr, PDBj:5btr
PDBsum	5btr
PubMed	26109052
UniProt	Q96EB6\|SIR1_HUMAN NAD-dependent protein deacetylase sirtuin-1 (Gene Name=SIRT1)

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