Structure of PDB 5b16 Chain A Binding Site BS02

Receptor Information
>5b16 Chain A (length=722) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAA
AAAAAAAAAAAAAALWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEA
IKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMF
AHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDIL
ELYDWNLKGPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKAAA
AAAAAAAAAAAAAAAATGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLI
GYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDTPSR
INHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAM
LAKKLELDRFMLYAHGPDLCRESDLRHAMANCFQALIGAVYLEGSLEEAK
QLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFE
EAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEY
LFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVA
LRTKTLADLLQSFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDP
KSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGC
GKGPSIQQAEMGAAMDALEKYN
Ligand information
>5b16 Chain C (length=23) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ANLHILSKLQEEMKRLAEEREET
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5b16 Structure of Human DROSHA
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E1112 A1113 I1114 V1116 E1193 D1233 E1235 Y1236 F1240 V1243
Binding residue
(residue number reindexed from 1)		E501 A502 I503 V505 E582 D622 E624 Y625 F629 V632
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004525 ribonuclease III activity
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0031054 pre-miRNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5b16, PDBe:5b16, PDBj:5b16
PDBsum5b16
PubMed26748718
UniProtQ9NRR4|RNC_HUMAN Ribonuclease 3 (Gene Name=DROSHA)

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