Structure of PDB 5axw Chain A Binding Site BS02

Receptor Information
>5axw Chain A (length=1043) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RNYILGLDIGITSVGYGIIDYETRDVIDAGVRLFKEANVENNEGRRSKRG
ARRLKRRRRHRIQRVKKLLFDYNLLTDHSELSGINPYEARVKGLSQKLSE
EEFSAALLHLAKRRGVHNVNEVEEDTGNELSTKEQISRNSKALEEKYVAE
LQLERLKKDGEVRGSINRFKTSDYVKEAKQLLKVQKAYHQLDQSFIDTYI
DLLETRRTYYEGPGEGSPFGWKDIKEWYEMLMGHCTYFPEELRSVKYAYN
ADLYNALNDLNNLVITRDENEKLEYYEKFQIIENVFKQKKKPTLKQIAKE
ILVNEEDIKGYRVTSTGKPEFTNLKVYHDIKDITARKEIIENAELLDQIA
KILTIYQSSEDIQEELTNLNSELTQEEIEQISNLKGYTGTHNLSLKAINL
ILDELWHTNDNQIAIFNRLKLVPKKVDLSQQKEIPTTLVDDFILSPVVKR
SFIQSIKVINAIIKKYGLPNDIIIELAREKNSKDAQKMINEMQKRNRQTN
ERIEEIIRTTGKENAKYLIEKIKLHDMQEGKCLYSLEAIPLEDLLNNPFN
YEVDHIIPRSVSFDNSFNNKVLVKQEEASKKGNRTPFQYLSSSDSKISYE
TFKKHILNLAKGKGRISKTKKEYLLEERDINRFSVQKDFINRNLVDTRYA
TRGLMNLLRSYFRVNNLDVKVKSINGGFTSFLRRKWKFKKERNKGYKHHA
EDALIIANADFIFKEWKKLDKAKKVMENQMFMPEIETEQEYKEIFITPHQ
IKHIKDFKDYKYSHRVDKKPNRELINDTLYSTRKDDKGNTLIVNNLNGLY
DKDNDKLKKLINKSPEKLLMYHHDPQTYQKLKLIMEQYGDEKNPLYKYYE
ETGNYLTKYSKKDNGPVIKKIKYYGNKLNAHLDITDDYPNSRNKVVKLSL
KPYRFDVYLDNGVYKFVTVKNLDVIKKENYYEVNSKAYEEAKKLKKISNQ
AEFIASFYNNDLIKINGELYRVIGVNNDLLNRIEVNMIDITYREYLENMN
DKRPPRIIKTIASKTQSIKKYSTDILGNLYEVKSKKHPQIIKK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5axw Crystal Structure of Staphylococcus aureus Cas9.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		N120 Y211 W229 Y230 L233 G235 R245 N264 Y313 R314 T390 G391 T392 N413 N419 L446 Y651 R654 N785 D786 T787 Y789 K815 Y882 R1012 P1013 T1019
Binding residue
(residue number reindexed from 1)		N118 Y209 W227 Y228 L231 G233 R243 N262 Y311 R312 T388 G389 T390 N411 N417 L444 Y649 R652 N776 D777 T778 Y780 K806 Y873 R1003 P1004 T1010
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0043571 maintenance of CRISPR repeat elements
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5axw, PDBe:5axw, PDBj:5axw
PDBsum5axw
PubMed26317473
UniProtJ7RUA5|CAS9_STAAU CRISPR-associated endonuclease Cas9 (Gene Name=cas9)

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