Structure of PDB 5axh Chain A Binding Site BS02

Receptor Information
>5axh Chain A (length=586) Species: 340099 (Thermoanaerobacter pseudethanolicus ATCC 33223) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IFSFKDDNNIVALTKGKLISDVYTDKARYYPSDKVTVKIELNNELQEDFR
GTIYIFYKHLESIVGKAKIQVNIKSGQKKQLNIFWEAPKDDFKGYLVEVY
AVKGNKAIDNKNTAVDVSSDWSKFPRYGYIANFPEQSKEKSALIIEDLNK
YHLNGLLFYDWQYKHNKPLAGTVENPDPKWKDIANRDIYGQTVKDYIELA
HSKNIMVANYNLMYGGYFDYVKDGAKPEWGLYKDPNHEEQDNHPLPHTWA
TDRLYLFNPANKDWQNYIFNAEKDAFRVYNFDVWHVGTLGPRGMVYDYNG
NPVELSFTYADFLNNAKNALGKRIVCNTVNEYGLINVASGADVDFLYVEI
WPPARAHYNFLKQTVDNGYNYSDGKKATVVAAYMNYGIADRSAEFNKHSV
RLTDAAIFAAGGDHIELGDTGMLSKEYFPSANLKMSESLVKAMRNYYDFL
TAYENLLRDGLKESDNKIEIPGIEISNNGSARTVWTYAKQKDGYDVIHMI
NLLGIEVSNWRDDLGNYSAPPIIKDFKVKYYLENDNIKNVYLASPDINDG
KVMKLQFKKKEDSKGKYLEISVPELQYWDMIFIKKL
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain5axh Chain C Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5axh Crystal structure of thermophilic dextranase from Thermoanaerobacter pseudethanolicus
Resolution2.2 Å
Binding residue
(original residue number in PDB)		Y184 D185 H190 Y235 L237 H268 Y452
Binding residue
(residue number reindexed from 1)		Y159 D160 H165 Y210 L212 H243 Y427
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.1.11: dextranase.
Gene Ontology
Molecular Function
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0033904 dextranase activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5axh, PDBe:5axh, PDBj:5axh
PDBsum5axh
PubMed26494689
UniProtB0KBZ7

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