Structure of PDB 5awh Chain A Binding Site BS02

Receptor Information
>5awh Chain A (length=759) Species: 349102 (Cereibacter sphaeroides ATCC 17025) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMQLVSNGFEVNLPDQVEVIVRDLPDPSKVKEERTRLMGYWFVHWFDGKL
FHLRIKAGGPNVDGEHRAIRTAEHPWLLRARLDDALEEALPKYAAVKKRP
FTFLAQKDELIDAAATAAGLSHRLLNSFKVIPRFALSPKIYEPVDGTTRV
GVFVTIGMRYDIEASLRDLLEAGIDLRGMYVVRRKRQPGERGLLGRVRAI
SDDMVQLFEETDLASVNVNDAKLEGSKENFTRCLSALLGHNYKKLLNALD
DQEAGYRTGPRFDDAVRRMGEFLAKKPIRLADNINAQVGDRIVFSNEGQA
RNVRLAPKVEYVFDRTGAKSAEYAWRGLSQFGPFDRPSFANRSPRILVVY
PSSTQGKVENFLSAFRDGMGSNYSGFSKGFVDLMGLTKVEFVMCPVEVSS
ADRNGAHTKYNSAIEDKLAGAGEVHAGIVVLFEDHARLPDDRNPYIHTKS
LLLTLGVPTQQVRMPTVLLEPKSLQYTLQNFSIATYAKLNGTPWTVNHDK
AINDELVVGMGLAELSGSRTEKRQRFVGITTVFAGDGSYLLGNVSKECEY
EGYSDAIRESMTGILRELKKRNNWRPGDTVRVVFHAHRPLKRVDVASIVF
ECTREIGSDQNIQMAFVTVSHDHPFVLIDRSERGLEAYKGSTARKGVFAP
PRGAISRVGRLTRLLAVNSPQLIKRANTPLPTPLLVSLHPDSTFKDVDYL
AEQALKFTSLSWRSTLPAATPVTIFYSERIAELLGRLKSIPNWSSANLNI
KLKWSRWFL
Ligand information
Receptor-Ligand Complex Structure
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PDB5awh Structural basis for the recognition of guide RNA and target DNA heteroduplex by Argonaute.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		P45 K49 R52 H62 W63 R97 K157 E246 Y260 Y329 Y341 Y494 A531 E532 R541 H605 S638 H639 D640 Q689 L690
Binding residue
(residue number reindexed from 1)		P27 K31 R34 H44 W45 R79 K139 E228 Y242 Y311 Y323 Y476 A513 E514 R523 H587 S620 H621 D622 Q671 L672
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004520 DNA endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5awh, PDBe:5awh, PDBj:5awh
PDBsum5awh
PubMed27325485
UniProtA4WYU7|AGO_CERS5 Protein argonaute (Gene Name=ago)

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