Structure of PDB 5amr Chain A Binding Site BS02

Receptor Information
>5amr Chain A (length=1657) Species: 11577 (La Crosse virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMDYQEYQQFLARINTARDACVAKDIDVDLLMARHDYFGRELCKSLNIEY
RNDVPFIDIILDIRPEVDPLTIDAPHITPDNYLYINNVLYIIDYKVSVSN
ESSVITYDKYYELTRDISDRLSIPIEIVIIRIDPVSRDLHINSDRFKELY
PTIVVDINFNQFFDLKQLLYEKFGDDEEFLLKVAHGDFTLTAPWCKTGCP
EFWKHPIYKEFKMSMPVPERRLFEESVKFNAYESERWNTNLVKIREYTKK
DYSEHISKSAKNIFLASGFYKQPNKNEISEGWTLMVERVQDQREISKSLH
DQKPSIHFIWGAHNPGNSNNATFKLILLSKSLQSIKGISTYTEAFKSLGK
MMDIGDKAIEYEEFCMSLKSKARSSWKQIMNKKLEPKQINNALVLWEQQF
MINNDLIDKSEKLKLFKNFCGIGKKQFKNKMLEDSKPKILDFDDANMYLA
SLTMMEQSKKILSKSNGLKPDNFILNEFGSRIKDANKETYDNMHKIFETG
YWQCISDFSTLMKNILSVSQYNRHNTFRIAMCANNNVFAIVFPSATVVYS
IIVLHKEEENIFNPGCLHGTFKCMNGYISISRAIRLDKERCQRIVSSPGL
FLTTCLLFKHDNPTLVMSDIMNFSIYTSLSITKSVLSLTEPARYMIMNSL
AISSNVKDYIAEKFSPYTKTLFSVYMTRLIKNACFDAYDQRQRVQLRDID
YDITQKGIKDNRELTSIWFPGSVTLKEYLTQIYLPFYFNAKGLHEKHHVM
VDLAKTILEIECEQRENIKEIWSTNCTKQTVNLKILIHSLCKNLLADTSR
HNHLRNRIENRNNFRRSITTISTFTSSKSCLKIGDFRKEKELQSVKQKKI
LEVQSRKMRLANYEMLRNAMPNYTDYISTKVFDRLYELLDKKVLTDKPVI
EQIMDMMIDHKKFYFTFFNEIFVGEYEAKMCMYAVERIAKERCKLNPDEM
ISEPGDGKLKVLEQKSEQEIRFLVETTRQKNREIDEAIEALLGKIEKLSL
GKAKGLKMEINADMSKWSAQDVFYKYFWLIALDPILYPQEKERILYFMCN
YMDKELILPDELLFNLLDQKVAYQNDIIATMTNQLNSNTVLIKRNWLQGN
FNYTSSYVHSCAMSVYKEILKEAITLLDGSILVNSLVHSDDNQTSITIVQ
DKMENDKIIDFAMKEFERACLTFGCQANMKKTYVTNCIKEFVSLFNLYGE
PFSIYGRFLLTSVGDCAYIGPYEDLASRISSAQTAIKHGCPPSLAWVSIA
ISHWMTSLTYNMLPGQSNDPIDYFPAENRKDIPIELNGVLDAPLSMISTV
GLESGNLYFLIKLLSKYTPVMQKRESVVNQIAEVKNWKVEDLTDNEIFRL
KILRYLVLDSILTPRKFTGSLRKLYSFSKYQDRLSSPGGMVELFTYLLEK
PELLVTKGEDMKDYMESVIFRYNSKRFKESLSIQNPAQLFIEQILFSHKP
VIDFSGIRDKYINILGKVTFTEAYRLLMRDLSSLELTNDDIQVIYSYIIL
NDPMMITIANTHILSIYGSPQRRMGMSCSTMPEFRNHHSPALVLRAYSNN
PDIPTEMARDLVHLKEFVENTNLEEKMKVRIAMNEAEKGQRDIVFELKEM
TRFYQVCYEYVKSTEHKIKVFILPAKSYTTTDFCSLMQGNLIKDKEWYTV
HYLKQIL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5amr Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Resolution2.57 Å
Binding residue
(original residue number in PDB)		M379 N380
Binding residue
(residue number reindexed from 1)		M380 N381
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5amr, PDBe:5amr, PDBj:5amr
PDBsum5amr
PubMed26004069
UniProtA5HC98|L_BUNLC RNA-directed RNA polymerase L (Gene Name=L)

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