Structure of PDB 5a43 Chain A Binding Site BS02

Receptor Information

>5a43 Chain A (length=124) Species: 585035 (Escherichia coli S88) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

IKSLFAVIIGGSVGCTLRWLLSTKFNSLFPNLPPGTLVVNLLAGLIIGTM
LAYFLRQPHLDPFWKLMITTGLCGGLSTFSTFSVEVFALLQAGNYIWALT
SVLVHVIGSLIMTALGFFIITILF

Ligand information

InChI=1S/FH/h1H/p-1

KRHYYFGTRYWZRS-UHFFFAOYSA-M

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[F-]

Formula

F

Name

FLUORIDE ION

PDB chain

5a43 Chain B Residue 1128 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	5a43 Crystal Structures of a Double-Barrelled Fluoride Ion Channel.
Resolution	2.58 Å
Binding residue (original residue number in PDB)	N41 G45
Binding residue (residue number reindexed from 1)	N40 G44
Annotation score	5

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0046872	metal ion binding
GO:0062054	fluoride channel activity
GO:1903425	fluoride transmembrane transporter activity

	Biological Process
GO:0034220	monoatomic ion transmembrane transport
GO:0140114	cellular detoxification of fluoride
GO:1903424	fluoride transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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External links

PDB	RCSB:5a43, PDBe:5a43, PDBj:5a43
PDBsum	5a43
PubMed	26344196
UniProt	B7LI20\|FLUC_ECO45 Fluoride-specific ion channel FluC (Gene Name=fluC)

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