Structure of PDB 5a0v Chain A Binding Site BS02

Receptor Information

>5a0v Chain A (length=454) Species: 100226 (Streptomyces coelicolor A3(2))

SHPHPELGRPPALPKGGLRVTPLGGLGEIGRNMTVFEYGGRLLIVDCGVL
FPEEEQPGIDLILPDFTSIRDRLDDIEGIVLTHGHEDHIGGVPFLLREKP
DIPLIGSKLTLALIEAKLQEHRIRPYTLEVAEGHRERVGPFDCEFVAVNH
SIPDALAVAIRTPAGMVVHTGDFKMDQLPLDGRLTDLHAFARLSEEGIDL
LLADSTNAEVPGFVPPERDISNVLRQVFANARKRIIVASFASHVHRIQQI
LDAAHEYGRRVAFVGRSMVRNMGIARDLGYLKVPPGLVVDVKTLDDLPDS
EVVLVCTGSQGEPMAALSRMANRDHQIRIVNGDTVILASSLIPGNENAVY
RVINGLTRWGANVVHKGNAKVHVSGHASAGELLYFYNICRPKNLMPVHGE
WRHLRANAELGALTGVPHDRIVIAEDGVVVDLVEGKAKITGKVQAGYVYV
DGLS

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5a0v Chain A Residue 1456

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5a0v Linkage of Catalysis and 5' End Recognition in Ribonuclease Rnase J
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): D88 H89 D173 H399
• Binding residue (residue number reindexed from 1): D87 H88 D172 H398
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0004527 exonuclease activity
• GO:0004534 5'-3' RNA exonuclease activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0006396 RNA processing

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5a0v, PDBe:5a0v, PDBj:5a0v
• PDBsum: 5a0v
• PubMed: 26253740
• UniProt: O86842