Structure of PDB 4zyo Chain A Binding Site BS02

Receptor Information
>4zyo Chain A (length=298) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DIYDPTYADAAGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWL
WGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYE
WARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDL
SDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFL
RYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHH
SFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4zyo Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4zyo Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		H160 H269 H298 H302
Binding residue
(residue number reindexed from 1)		H108 H217 H246 H250
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.19.1: stearoyl-CoA 9-desaturase.
Gene Ontology
Molecular Function
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

View graph for
Molecular Function
External links
PDB RCSB:4zyo, PDBe:4zyo, PDBj:4zyo
PDBsum4zyo
PubMed26098317
UniProtO00767|SCD_HUMAN Stearoyl-CoA desaturase (Gene Name=SCD)

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