Structure of PDB 4zwb Chain A Binding Site BS02

Receptor Information
>4zwb Chain A (length=468) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFITKTLTDKGNA
PPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAV
TGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRG
AFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAAL
PFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQE
KQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ
EPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVS
LLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAM
AVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPE
TRGRTFEDITRAFEGQAH
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain4zwb Chain B Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4zwb Molecular basis of ligand recognition and transport by glucose transporters
Resolution2.4 Å
Binding residue
(original residue number in PDB)		T28 N286 N413
Binding residue
(residue number reindexed from 1)		T26 N284 N411
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005353 fructose transmembrane transporter activity
GO:0005354 galactose transmembrane transporter activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0015755 fructose transmembrane transport
GO:0015757 galactose transmembrane transport
GO:0019852 L-ascorbic acid metabolic process
GO:0046323 D-glucose import
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
GO:0098708 D-glucose import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1904659 D-glucose transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016235 aggresome
GO:0030667 secretory granule membrane
GO:0035579 specific granule membrane
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zwb, PDBe:4zwb, PDBj:4zwb
PDBsum4zwb
PubMed26176916
UniProtP11169|GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 (Gene Name=SLC2A3)

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