Structure of PDB 4zgn Chain A Binding Site BS02

Receptor Information

>4zgn Chain A (length=279) Species: 284812 (Schizosaccharomyces pombe 972h-)

LVPRGSHMTLILTKNQVLHCQFSSWYSLFRKLTPKAKVIKPIPATVLKYL
HEDSIYVEQAYYPEREAIQLIEKAIKELGGAVVPKLNWSTPKDALWITTT
GSLKCTTAEEVLLLLKSSDFVAHDLNHAFDDCKDFDNADPKDFSFELVLK
EWFPMHASTEFRCFVKSKRLIAFCQRDDNYYEFLKENIDCYEKLISDLLK
KLDTFPDPDFVFDVYIHKDRAWLIDINPFYPRTDGLLFSWSELESMNSEN
MKPEIRLIPKASEGENLLEFAQKWQDLTN

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4zgn Chain A Residue 402

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4zgn Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): D239 N241
• Binding residue (residue number reindexed from 1): D225 N227
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0044183 protein folding chaperone
• GO:0046872 metal ion binding

Biological Process

• GO:0006457 protein folding
• GO:1905143 eukaryotic translation initiation factor 2 complex assembly

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4zgn, PDBe:4zgn, PDBj:4zgn
• PDBsum: 4zgn
• PubMed: 26211610
• UniProt: Q9P7N5|CD123_SCHPO Translation initiation factor eIF2 assembly protein (Gene Name=cdc123)