Structure of PDB 4z53 Chain A Binding Site BS02

Receptor Information
>4z53 Chain A (length=690) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKAYAWTDGELEELRKLQRYKG
LGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKW
IEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRI
LYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKN
REILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWN
FDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMI
DHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEI
EKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRD
GLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVP
ILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRA
SENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELRE
KIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED
Ligand information
Receptor-Ligand Complex Structure
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PDB4z53 Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.26 Å
Binding residue
(original residue number in PDB)		I460 N461 K464 H513 V626 R629 R630 Y1118 I1170 S1171 G1173 Y1174 A1175 R1235
Binding residue
(residue number reindexed from 1)		I46 N47 K50 H99 V194 R197 R198 Y324 I376 S377 G379 Y380 A381 R441
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z53, PDBe:4z53, PDBj:4z53
PDBsum4z53
PubMed
UniProtP72525|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC);
Q59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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