Structure of PDB 4z2d Chain A Binding Site BS02

Receptor Information

>4z2d Chain A (length=485) Species: 1313 (Streptococcus pneumoniae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QDKNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMN
ELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLV
DGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANE
REPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEV
TTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKT
GRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFV
IEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAY
IEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDA
EAQAELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADL
ADILAKPERVSQIIKDELDEVKRKFSDKRRTELMV

Ligand information

>4z2d Chain F (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gatcatacaac

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4z2d Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution	3.38 Å
Binding residue (original residue number in PDB)	R119 I172 A173 V174 G175 M176
Binding residue (residue number reindexed from 1)	R118 I171 A172 V173 G174 M175

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

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Molecular Function

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Biological Process

External links

PDB	RCSB:4z2d, PDBe:4z2d, PDBj:4z2d
PDBsum	4z2d
PubMed
UniProt	Q8DPM2\|GYRA_STRR6 DNA gyrase subunit A (Gene Name=gyrA)

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