Structure of PDB 4yoc Chain A Binding Site BS02

Receptor Information
>4yoc Chain A (length=882) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PTKATTTKLVYQIFDTFFADEEVDDNIPEMPSPKKMHQGKKKKQNKNRIS
WVGEAVKTDGKKSYYKKVCIDAETLEVGDCVSVIPDDSSKPLYLARVTAL
WEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKV
KVIYKAPSENWAMEGGMDPESGKTYFYQLWYDQDYARFESPPKTQPTEDN
KFKFCVSCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDG
VYLPPEAFTFNIKLEPVDEDLYPEHYRKYSDYNLDAPEPYRIGRIKEIFC
PKKSNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVV
DFKAVQGRCTVEYGEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPN
HARSPGNKGKGKGKEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIE
MWDPAAQAFRLNNPGSTVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVE
MLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLLENV
RNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAA
APGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTITVR
DTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMS
ALVAARMRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSS
SGALRGVCSCVEAGKACDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLE
WDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDTYRLFGN
ILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4yoc Chain A Residue 1702 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4yoc Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.
Resolution2.916 Å
Binding residue
(original residue number in PDB)		H793 C820 C893 C896
Binding residue
(residue number reindexed from 1)		H111 C138 C205 C208
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) C1226 E1266 R1310 R1312
Catalytic site (residue number reindexed from 1) C508 E548 R592 R594
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006346 DNA methylation-dependent heterochromatin formation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4yoc, PDBe:4yoc, PDBj:4yoc
PDBsum4yoc
PubMed25960197
UniProtP26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)

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