Structure of PDB 4ykp Chain A Binding Site BS02

Receptor Information

>4ykp Chain A (length=247) Species: 27923 (Mnemiopsis leidyi)

LIGRHLRLGSVEEQPFMFFATEGCEGNDCWSGMVNDMVVKLSEDLGFTYE
YIQPDDRKFGALNKTTNEWNGMIRDLLDDKTDMIAIDLSTNSARKSAIDY
SFPFMDAGIKAVVKGEGTTLNQVLELLDQDKYKWGVIGSRHPETLLKTHR
DSRYSRLVDEGVELKDLNHAIETLRGGLFVFIDEGPVLAHNLISDCDVFS
VGEEFQSFEYAFGLPKDSPYKSLIDSHLLKFREEGFIDILWEKWSSG

Ligand information

• Ligand ID: SER
• InChI: InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
• InChIKey: MTCFGRXMJLQNBG-REOHCLBHSA-N
• SMILES:
  CACTVS 3.341: N[CH](CO)C(O)=O
  OpenEye OEToolkits 1.5.0: C(C(C(=O)O)N)O
  CACTVS 3.341: N[C@@H](CO)C(O)=O
  ACDLabs 10.04: O=C(O)C(N)CO
  OpenEye OEToolkits 1.5.0: C([C@@H](C(=O)O)N)O
• Formula: C3 H7 N O3
• Name: SERINE
• ChEMBL: CHEMBL11298
• DrugBank: DB00133
• ZINC: ZINC000000895034
• PDB chain: 4ykp Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4ykp Glycine activated ion channel subunits encoded by ctenophore glutamate receptor genes.
• Resolution: 1.46 Å
• Binding residue (original residue number in PDB): E17 F63 D91 L92 S93 R98 R144 H145 E188
• Binding residue (residue number reindexed from 1): E13 F59 D87 L88 S89 R94 R140 H141 E184
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0015276 ligand-gated monoatomic ion channel activity
• GO:0046872 metal ion binding

Biological Process

• GO:0034220 monoatomic ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4ykp, PDBe:4ykp, PDBj:4ykp
• PDBsum: 4ykp
• PubMed: 26460032
• UniProt: A0A0R4I973