Structure of PDB 4yix Chain A Binding Site BS02

Receptor Information
>4yix Chain A (length=579) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SPLMDFFHSVEGRNYGELRSLTNETYQISENVRCTFLSIQSDPFAPGSQV
RLVCPCTFSLEKVLQTTDLAAANPCRRVAAEDFILRSFHAGYRNGIPRRT
SGAVQVLRPSQHVLERSTVGLVKEIEIFARVKLPGGRRIDGHGAIDIFYN
ELVPLLEQCVVGLNEEDLHQHVICVHDQEELRSNLLGAGYVAFVANGAIL
PRDAGNSDKPLRDNAVPFQSPKSLECSFTLPHSGKTITGMGLPPGLTLIA
GGGFHGKSTLLRALEVGIYNHVPDDGRTYVVVDPTAVKIRAEDRRSVHGV
DISPFINNLPFGKTTNFFVTADASGSTSQAANIMEALELGSQLLLLDEDT
CATNLMYRDALMQMLVPRAQEPITPFVERVADLSQNHGVSSIMVIGGSGQ
YFPQARVVLVMNAYQISDCTKEAKEIASNSSSVFIPDVNRCFDPDGSFTT
VRTKVSGIGTESIRFSEETIDLSMVEQIVEEGQVNAIAQCLALLYDGEPR
IVPEMTTKGGALTQLPSPGGVCFNSNFSSMIAGCCSHQHDKRLELRTPSC
YLPRGFTSATRHIEIGAALNRLRTLRTVT
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4yix Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4yix Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		C570 C620
Binding residue
(residue number reindexed from 1)		C490 C534
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000963 mitochondrial RNA processing
GO:0016554 cytidine to uridine editing
GO:0048255 mRNA stabilization
GO:0090615 mitochondrial mRNA processing
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0031019 mitochondrial mRNA editing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4yix, PDBe:4yix, PDBj:4yix
PDBsum4yix
PubMed26117548
UniProtQ57ZF2

[Back to BioLiP]