Structure of PDB 4ydx Chain A Binding Site BS02

Receptor Information
>4ydx Chain A (length=67) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTL
LATLKKTGKTVSYLGLE
Ligand information
Ligand IDTCE
InChIInChI=1S/C9H15O6P/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15/h1-6H2,(H,10,11)(H,12,13)(H,14,15)
InChIKeyPZBFGYYEXUXCOF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC(=O)CCP(CCC(O)=O)CCC(O)=O
OpenEye OEToolkits 1.5.0C(CP(CCC(=O)O)CCC(=O)O)C(=O)O
ACDLabs 10.04O=C(O)CCP(CCC(=O)O)CCC(=O)O
FormulaC9 H15 O6 P
Name3,3',3''-phosphanetriyltripropanoic acid;
3-[bis(2-carboxyethyl)phosphanyl]propanoic acid
ChEMBLCHEMBL171512
DrugBank
ZINCZINC000002517013
PDB chain4ydx Chain A Residue 103 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ydx Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
Resolution1.602 Å
Binding residue
(original residue number in PDB)		C12 C15 K60
Binding residue
(residue number reindexed from 1)		C11 C14 K59
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0016530 metallochaperone activity
GO:0016531 copper chaperone activity
GO:0032767 copper-dependent protein binding
GO:0046872 metal ion binding
GO:1903136 cuprous ion binding
Biological Process
GO:0006825 copper ion transport
GO:0006878 intracellular copper ion homeostasis
GO:0006979 response to oxidative stress
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ydx, PDBe:4ydx, PDBj:4ydx
PDBsum4ydx
PubMed26327386
UniProtO00244|ATOX1_HUMAN Copper transport protein ATOX1 (Gene Name=ATOX1)

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