Structure of PDB 4y5w Chain A Binding Site BS02

Receptor Information

>4y5w Chain A (length=478) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KFKTGLRRLQHRVGEIHLLREALQKALAMLLQETTGELEAAKALVLKRIQ
IWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGETRAS
LTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGPAK
PPLVRADMVTEKQARETGEIINNTVPLENSIPGNCCSALFKNLLLKKIKR
CERKGTESVTEEKCAVLFSASFTLGLPIQLQALSLPLVVIVHGNQDNNAK
ATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEH
FLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLD
LTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITI
AHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDE
AFRSHYKPEQMGKDGRGYVPATIKMTVE

Ligand information

>4y5w Chain N (length=22) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tctgtcttcctaggaaatccat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4y5w Structural basis for DNA recognition by STAT6
Resolution	3.104 Å
Binding residue (original residue number in PDB)	R370 S378 V379 V414
Binding residue (residue number reindexed from 1)	R200 S208 V209 V241
Binding affinity	PDBbind-CN: Kd=79nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0007165	signal transduction

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Molecular Function

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Biological Process

External links

PDB	RCSB:4y5w, PDBe:4y5w, PDBj:4y5w
PDBsum	4y5w
PubMed	27803324
UniProt	P42226\|STAT6_HUMAN Signal transducer and activator of transcription 6 (Gene Name=STAT6)

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