Structure of PDB 4xvm Chain A Binding Site BS02

Receptor Information
>4xvm Chain A (length=627) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSS
VRGIVVLVKRQACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARN
VLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAW
LIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTL
YRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTS
ALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLKYPSTSEA
VLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKKILTISPRAMFVSSKGHTFLAADF
SQIELRILTHLSGDPELLKLDDVFSTLTSQWKDVPVEQVTHADREQTKKV
VYAVVYGAGKERLAACVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQT
GCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIH
VFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQ
ALELQLQVPLKVSLSAGRSWGHLVPLQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4xvm How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R571 Q580 G581 S583 K584 R608 E628 K679 Y682 Y686 I801 H802 D803
Binding residue
(residue number reindexed from 1)		R354 Q363 G364 S366 K367 R384 E404 K449 Y452 Y456 I569 H570 D571
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4xvm, PDBe:4xvm, PDBj:4xvm
PDBsum4xvm
PubMed25775266
UniProtQ7Z5Q5|DPOLN_HUMAN DNA polymerase nu (Gene Name=POLN)

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