Structure of PDB 4xvk Chain A Binding Site BS02

Receptor Information
>4xvk Chain A (length=630) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSS
VRGIVVLVKRQACGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFARN
VLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIAAW
LIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLKTL
YRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTS
ALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSYPSTSE
AVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTG
TVTGRLSAKHPNIQGISKHPIQITTPKKILTISPRAMFVSSKGHTFLAAD
FSQIELRILTHLSGDPELLKLDDVFSTLTSQWKDVPVEQVTHADREQTKK
VVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQC
HQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLA
MIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLE
QVQALELQLQVPLKVSLSAGRSWGHLVPLQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4xvk How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		T479 S480 N482 S543 T544 T567 V568 T569 A574 K575 H576 N578 Y686 A688 R692 R743 Q754 R761 Q762 N765
Binding residue
(residue number reindexed from 1)		T275 S276 N278 S327 T328 T351 V352 T353 A358 K359 H360 N362 Y457 A459 R463 R514 Q525 R532 Q533 N536
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4xvk, PDBe:4xvk, PDBj:4xvk
PDBsum4xvk
PubMed25775266
UniProtQ7Z5Q5|DPOLN_HUMAN DNA polymerase nu (Gene Name=POLN)

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