Structure of PDB 4xvi Chain A Binding Site BS02

Receptor Information
>4xvi Chain A (length=647) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KKHFCDIRHLDDWAKSQLIEMLKQAAALVITVMYTDGSTQLGADQTPVSS
VRGIVVLVKRQAEGCGPVLEGFVSDDPCIYIQIEHSAIWDQEQEAHQQFA
RNVLFQTMKCKCPVICFNAKDFVRIVLQFFGNDGSWKHVADFIGLDPRIA
AWLIDPSDATPSFEDLVEKYCEKSITVKVNSTYGNSSRNIVNQNVRENLK
TLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEK
TSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNS
LPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLAC
MKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKKILTISPRA
MFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQRDDVFSTLTSQWK
DVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFL
QKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQ
AVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDP
QIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4xvi How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T479 S480 S543 T544 T567 V568 A574 K575 H576 N578 Y686 R743 Q762
Binding residue
(residue number reindexed from 1)		T277 S278 S341 T342 T365 V366 A372 K373 H374 N376 Y474 R531 Q550
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4xvi, PDBe:4xvi, PDBj:4xvi
PDBsum4xvi
PubMed25775266
UniProtQ7Z5Q5|DPOLN_HUMAN DNA polymerase nu (Gene Name=POLN)

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