Structure of PDB 4xr1 Chain A Binding Site BS02

Receptor Information
>4xr1 Chain A (length=307) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RYDLVDRLNTTFRQMEQELAIFAAHLEQHKLLVARVFSLPEVKKEDEHNP
LNRIEVKQHLGNDAQSLALRHFRHLFIQQQSENRSSKAAVRLPGVLCYQV
DNLSQAALVSHIQHINKLKTTFEHIVTVESELPTAARFEWVHRHLPGLIT
LNAYRTLTVLHDPATLRFGWANKHIIKNLHRDEVLAQLEKSLKSPRSVAP
WTREEWQRKLEREYQDIAALPQNAKLKIKRPVKVQPIARVWYKGDQKQVQ
HACPTPLIALINRDNGAGVPDVGELLNYDADNVQHRYKPQAQPLRLIIPR
LHLYVAD
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4xr1 Replisome speed determines the efficiency of the Tus-Ter replication termination barrier.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		H50 K89 A90 A91 R93 R157 T158 K175 S193 P197 R198 R232 V234 Q237 Q252 R288 Y289 R302
Binding residue
(residue number reindexed from 1)		H48 K87 A88 A89 R91 R155 T156 K173 S191 P195 R196 R230 V232 Q235 Q250 R286 Y287 R300
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006260 DNA replication
GO:0006274 DNA replication termination
GO:0071807 replication fork arrest involved in DNA replication termination
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4xr1, PDBe:4xr1, PDBj:4xr1
PDBsum4xr1
PubMed26322585
UniProtP16525|TUS_ECOLI DNA replication terminus site-binding protein (Gene Name=tus)

[Back to BioLiP]