Structure of PDB 4xpz Chain A Binding Site BS02

Receptor Information

>4xpz Chain A (length=364) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

RLESENVKRLRQEKRLSLIVDLDQTIIHATVDPTVGEWMSDPGNVNYDVL
RDVRSFNLQEGPSGYTSCYYIKFRPGLAQFLQKISELYELHIYTMGTKAY
AKEVAKIIDPTGKLFQDRVLSADDSGSLAQKSLRRLFPCDTSMVVVIDDR
GDVWDWNPNLIKVVPYEFFVGIGDINSNFLGSNREALEEQNKERVTALEL
QKSERPLAKQQNALLEDPSHTLLHNRDHELERLEKVLKDIHAVYYEEEND
ISSRSGNHKHANVGLIIPKMKQKVLKGCRLLFSGVIPLGVDVLSSDIAKW
AMSFGAEVVLDFSVPPTHLIAAKIRTEKVKKAVSMGNIKVVKLNWLTESL
SQWKRLPESDYLLY

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

4xpz Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4xpz Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.
Resolution	1.45 Å
Binding residue (original residue number in PDB)	D170 D172 D298
Binding residue (residue number reindexed from 1)	D21 D23 D149
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.16: protein-serine/threonine phosphatase.

Gene Ontology

	Molecular Function
GO:0004721	phosphoprotein phosphatase activity
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Cellular Component

External links

PDB	RCSB:4xpz, PDBe:4xpz, PDBj:4xpz
PDBsum	4xpz
PubMed	25883047
UniProt	Q9P376\|FCP1_SCHPO RNA polymerase II subunit A C-terminal domain phosphatase (Gene Name=fcp1)

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