Structure of PDB 4xeg Chain A Binding Site BS02

Receptor Information
>4xeg Chain A (length=196) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFW
KCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFRE
GGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIP
DTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4xeg Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Resolution1.72 Å
Binding residue
(original residue number in PDB)		N140 N157 S200 K201 G231 K232 C233 P270 S271 S273 A274 R275 C276 Q278
Binding residue
(residue number reindexed from 1)		N30 N47 S90 K91 G121 K122 C123 P160 S161 S163 A164 R165 C166 Q168
Enzymatic activity
Catalytic site (original residue number in PDB) N140 H151
Catalytic site (residue number reindexed from 1) N30 H41
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

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Molecular Function
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Biological Process
External links
PDB RCSB:4xeg, PDBe:4xeg, PDBj:4xeg
PDBsum4xeg
PubMed26358812
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

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