Structure of PDB 4x9p Chain A Binding Site BS02

Receptor Information
>4x9p Chain A (length=314) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDI
AFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMTDE
DSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALA
KGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHL
QKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLY
DSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKG
DYQKALLYLCGGDD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4x9p Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4x9p The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects.
Resolution2.01 Å
Binding residue
(original residue number in PDB)		G202 R205 K206 G207 E247
Binding residue
(residue number reindexed from 1)		G177 R180 K181 G182 E222
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001786 phosphatidylserine binding
GO:0004859 phospholipase inhibitor activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005544 calcium-dependent phospholipid binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0031214 biomineral tissue development
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0031982 vesicle
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0065010 extracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4x9p, PDBe:4x9p, PDBj:4x9p
PDBsum4x9p
PubMed25772737
UniProtP04272|ANXA2_BOVIN Annexin A2 (Gene Name=ANXA2)

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