Structure of PDB 4x5v Chain A Binding Site BS02

Receptor Information
>4x5v Chain A (length=317) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKYQEACSIPGIGKR
MAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFR
SLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNS
GLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLT
DDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTG
SAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKD
VFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB4x5v Nucleotide binding interactions modulate dNTP selectivity and facilitate 8-oxo-dGTP incorporation by DNA polymerase lambda.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		W342 G343 A344 G345 K347 T348 D427 D429 Y505 F506 T507 G508 A510 N513
Binding residue
(residue number reindexed from 1)		W84 G85 A86 G87 K89 T90 D169 D171 Y247 F248 T249 G250 A252 N255
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D169 D171 D232
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4x5v, PDBe:4x5v, PDBj:4x5v
PDBsum4x5v
PubMed26220180
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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