Structure of PDB 4x09 Chain A Binding Site BS02

Receptor Information
>4x09 Chain A (length=128) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MWPKRLTKAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLHDSFQ
NVAAVCDLLSIVCKNRRHNCHQSSKPVNMTDCRLTSGKYPQCRYSAAAQY
KFFIVACDPPQKSDPPYKLVPVHLDSIL
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain4x09 Chain A Residue 304 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4x09 The first crystal structure of human RNase 6 reveals a novel substrate-binding and cleavage site arrangement.
Resolution1.722 Å
Binding residue
(original residue number in PDB)		H36 H39
Binding residue
(residue number reindexed from 1)		H37 H40
Annotation score3
Enzymatic activity
Catalytic site (original residue number in PDB) H15 K38 H122 L123 D124
Catalytic site (residue number reindexed from 1) H16 K39 H123 L124 D125
Enzyme Commision number 3.1.27.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004519 endonuclease activity
GO:0004540 RNA nuclease activity
Biological Process
GO:0006401 RNA catabolic process
GO:0006952 defense response
GO:0019731 antibacterial humoral response
GO:0042742 defense response to bacterium
GO:0045087 innate immune response
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0051607 defense response to virus
GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0031410 cytoplasmic vesicle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4x09, PDBe:4x09, PDBj:4x09
PDBsum4x09
PubMed27013146
UniProtQ93091|RNAS6_HUMAN Ribonuclease K6 (Gene Name=RNASE6)

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