Structure of PDB 4wzm Chain A Binding Site BS02

Receptor Information
>4wzm Chain A (length=475) Species: 12120 (Foot-and-mouth disease virus (strain C1-Santa Pau)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLIVDTRDVEERVHVMRETKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAAALE
Ligand information
Receptor-Ligand Complex Structure
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PDB4wzm Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition.
Resolution2.52 Å
Binding residue
(original residue number in PDB)		Y336 D338 D339 L386 K387 R388 I411 R416 T419 E422 K423 S426
Binding residue
(residue number reindexed from 1)		Y336 D338 D339 L386 K387 R388 I411 R416 T419 E422 K423 S426
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.46: L-peptidase.
3.6.1.15: nucleoside-triphosphate phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4wzm, PDBe:4wzm, PDBj:4wzm
PDBsum4wzm
PubMed25903341
UniProtP03311|POLG_FMDVS Genome polyprotein

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