Structure of PDB 4wv6 Chain A Binding Site BS02

Receptor Information

>4wv6 Chain A (length=426) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSL
ACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADT
CWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIV
TGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGI
IEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQNHENESVYKASLSLIEKYFS

Ligand information

>4wv6 Chain C (length=3) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

KKS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4wv6 Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.
Resolution	1.75 Å
Binding residue (original residue number in PDB)	V321 T322 W357 N361 W399
Binding residue (residue number reindexed from 1)	V250 T251 W286 N290 W328

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:4wv6, PDBe:4wv6, PDBj:4wv6
PDBsum	4wv6
PubMed	25586196
UniProt	P52292\|IMA1_HUMAN Importin subunit alpha-1 (Gene Name=KPNA2)

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