Structure of PDB 4wtg Chain A Binding Site BS02

Receptor Information
>4wtg Chain A (length=535) Species: 356411 (Hepatitis C virus JFH-1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSMSYSWTGALITPCGPEEEKLPINPLSNSLLRYHNKVYCTTSKSASQRA
KKVTFDRTQVLDAHYDSVLKDIKLAASKVSARLLTLQQACQLTPPHSARS
KYGFGAKEVRSLSGRAVNHIKSVWKDLLEDPQTPIPTTIMAKNEVFCVDP
AKGGKKPARLIVYPDLGVRVCEKMALYDITQKLPQAVMGASYGFQYSPAQ
RVEYLLKAWAEKKDPMGFSYDTRHFDSTVTERDIRTEESIYQACSLPEEA
RTAIHSLTERLYVGGPMFNSKGQTCGYRRCRASGVLTTSMGNTITCYVKA
LAACKAAGIVAPTMLVCGDDLIVISESQGTEEDERNLRAFTEAMTRYSAP
PGDPPRPEYDLELITSCSSNVSVALGPRGRRRYYLTRDPTTPLARAAWET
VRHSPINSWLGNIIQYAPTIWVRMVLMTHFFSILMVQDTLDQNLGGVNPL
DLPAIIERLHGLDAFSMHTYSHHELTRVASALRKLGAPPLRVWKSRARAV
RASLISRGGKAAVCGRYLFNWAVKTKLKLTPLPEA
Ligand information
Receptor-Ligand Complex Structure
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PDB4wtg Structural basis for RNA replication by the hepatitis C virus polymerase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D319 C366 S367 R386 R394 N406 S407 G410 N411 Q414 G444
Binding residue
(residue number reindexed from 1)		D320 C367 S368 R387 R395 N407 S408 G411 N412 Q415 G445
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4wtg, PDBe:4wtg, PDBj:4wtg
PDBsum4wtg
PubMed25678663
UniProtQ99IB8|POLG_HCVJF Genome polyprotein

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