Structure of PDB 4wfa Chain A Binding Site BS02

Receptor Information

>4wfa Chain A (length=268) Species: 93061 (Staphylococcus aureus subsp. aureus NCTC 8325)

IKKYKPITNGRRNMTSLDFAEITKTTPEKSLLKPLPKKAGRNNQGKLTVR
HHGGGHKRQYRVIDFRNKDGINAKVDSIQYDPNRSANIALVVYADGEKRY
IIAPKGLEVGQIVESGAEADIKVGNALPLQNIPVGTVVHNIELKPGKGGQ
IARSAGASAQVLGKEGKYVLIRLRSGEVRMILSTCRATIGQVGNLQHELV
NVGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGRAPIGRPSPMSPWGKP
TLGKKTRRGKKSSDKLIV

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4wfa Chain X Residue 3335

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4wfa Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.
• Resolution: 3.392 Å
• Binding residue (original residue number in PDB): R221 V224
• Binding residue (residue number reindexed from 1): R218 V221
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0016740 transferase activity
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4wfa, PDBe:4wfa, PDBj:4wfa
• PDBsum: 4wfa
• PubMed: 26464510
• UniProt: P60430|RL2_STAA8 Large ribosomal subunit protein uL2 (Gene Name=rplB)