Structure of PDB 4ui9 Chain A Binding Site BS02

Receptor Information
>4ui9 Chain A (length=1441) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVKE
SWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVDSP
VQQALWCDFIISEVEKCICILQSSCINMHSIEGKDYIASLPFQVANVWPT
KYGLLFERSPLPTMFSMLHPLDEITPLVCKVQYVVDHAMKIVFLNTDPSI
VMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGFPQNVPIVPELCIDH
LWTNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESTQLIFGSVTN
IPAKDAAPVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGTYIHSIRDPV
HNRVTLELSNGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKW
YNVHSAPGGPSYHSEWNLFVTCLMNMMGYTHIPAIFFVLHLVYEELKLNT
LMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVSEPPSIYQWVSSC
LKGEGMPPYPYLPGICERSRLVVLSIALYILSSLAERLVVWMTNVGFILR
DLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSKQDDGMND
MNHEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSEHEFIEEKEN
RLLQLCQRTMALPVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTV
DLNSGNIDVPPNMTSWASFHNGVAAGLKIAPASQIDSAWIVYNKPKHAEL
ANEYAGFLMALGLNGHLTKLATLNIHDYLTKGHEMTSIGLLLGVSAAKLG
TMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLVYQGTAHRH
TAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSD
LNVPEQLYQYMVGGHSPSYQIKEGDTLNVDVTCPGATLALAMIYLKTNNR
SIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVP
QIIRENLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDF
MTYLSAPNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMK
TGGEMNYGFHLAHHMALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAH
STDNRYHLQALRHLYVLAAEPRLLVPVDVDTNTPCYALLEVLYKGTQWYE
QTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDLTQHLKSILSKDGVLY
VKLRAGQLSYKEDNSEARAFKSAFTSDPALLSFAEYFCKPTVNMGQKQEI
LDLFSSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLV
LEFFSSRSHQFMNSEFLPVVKCTIDNTLDQWLQVGGDMCVHAYLSPLESQ
LSMLACFLVYHSVPAPSTSFAELLFKFKQLKMPVRALLRLA
Ligand information
>4ui9 Chain W (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MLRRKPTRLELKLDDIEEFENIRKD
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ui9 Atomic Structure of the Apc and its Mechanism of Protein Ubiquitination
Resolution3.6 Å
Binding residue
(original residue number in PDB)		S1317 N1320
Binding residue
(residue number reindexed from 1)		S899 N902
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0060090 molecular adaptor activity
Biological Process
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0141198 protein branched polyubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005680 anaphase-promoting complex
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ui9, PDBe:4ui9, PDBj:4ui9
PDBsum4ui9
PubMed26083744
UniProtQ9H1A4|APC1_HUMAN Anaphase-promoting complex subunit 1 (Gene Name=ANAPC1)

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