Structure of PDB 4tqr Chain A Binding Site BS02

Receptor Information

>4tqr Chain A (length=342) Species: 273057 (Saccharolobus solfataricus P2)

MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEA
RKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIE
IASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVF
AKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN
KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVT
MKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGR
TFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFIE

Ligand information

>4tqr Chain T (length=18)

tcacggaatccttccccc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4tqr Kinetic and Structural Mechanisms of (5'S)-8,5'-Cyclo-2'-deoxyguanosine-Induced DNA Replication Stalling.
• Resolution: 1.58 Å
• Binding residue (original residue number in PDB): Y12 S34 G35 A44 T45 A57 K78 S103 I104 D105 A220 R242 K243 I245 G246 R247 I248 R336
• Binding residue (residue number reindexed from 1): Y12 S34 G35 A44 T45 A57 K78 S103 I104 D105 A220 R242 K243 I245 G246 R247 I248 R336

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4tqr, PDBe:4tqr, PDBj:4tqr
• PDBsum: 4tqr
• PubMed: 25569151
• UniProt: Q97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)