Structure of PDB 4tmu Chain A Binding Site BS02

Receptor Information
>4tmu Chain A (length=511) Species: 290339 (Cronobacter sakazakii ATCC BAA-894) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEVYSQETLAKQVLQETFGYQQFRPGQATIIDAVLEGRDCLVVMPTGGGK
SLCYQIPALVKTGLTIVVSPLISLMKDQVDQLLANGVAAACLNSTQSREE
QQAVLAGCRTGQVRLLYIAPERLMMDNFIDTLGYWDLAMVAVDEAHCISQ
WGHDFRPEYAALGQLRARFPAVPFMALTATADDTTRRDIVRLLGLDDPLI
EISSFDRPNIRYMLMEKFKPLDQLMRYVQEQRGKSGIIYCNSRAKVEDTA
ARLQSRGISAAAYHAGLEHEVRASVQEKFQRDDLQIVVATVAFGMGINKP
NVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADMAWLRRCLE
EKAPGPLQDIERHKLNAMGAFAEAQTCRRLVLLNYFGEGRQAPCGNCDIC
LDPPRRYDGLVDAQKALSAIARVEQRFGMGYVVEVLRGANNQRIRELGHD
KLKVYGIGRDQSQEHWVSVIRQLIHLGVVTQNIAQHSALQLTEAARPFLR
GEAPLMLAVPR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4tmu Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4tmu Structural mechanisms of DNA binding and unwinding in bacterial RecQ helicases.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		C380 C397 C400 C403
Binding residue
(residue number reindexed from 1)		C377 C394 C397 C400
Annotation score1
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0009432 SOS response

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Molecular Function
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Biological Process
External links
PDB RCSB:4tmu, PDBe:4tmu, PDBj:4tmu
PDBsum4tmu
PubMed25831501
UniProtA7MQK9

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