Structure of PDB 4rno Chain A Binding Site BS02

Receptor Information
>4rno Chain A (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGIIAV
SYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVM
EIMSRFAVIERASIDEAYVDLTSAVQERLQKLGQPISADLLPSTYIEGLP
QGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIER
ETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIR
SLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIE
HDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDR
NDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNC
NTSGIQTEWSPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4rno Structural and Kinetic Analysis of Nucleoside Triphosphate Incorporation Opposite an Abasic Site by Human Translesion DNA Polymerase eta.
Resolution2.82 Å
Binding residue
(original residue number in PDB)		S113 K224 S257 G259 G260 K261 L262 R377 S380 L381 R382 R383
Binding residue
(residue number reindexed from 1)		S113 K218 S251 G253 G254 K255 L256 R371 S374 L375 R376 R377
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4rno, PDBe:4rno, PDBj:4rno
PDBsum4rno
PubMed25666608
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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