Structure of PDB 4reo Chain A Binding Site BS02

Receptor Information

>4reo Chain A (length=221) Species: 274 (Thermus thermophilus)

RALLEKVDPNKIYTIDEAAHLVKELATAKFDETVEVHAKLGIDPRRSDQN
VRGTVSLPHGLGKQVRVLAIAKGEKIKEAEEAGADYVGGEEIIQKILDGW
MDFDAVVATPDVMGAVGSKLGRILGPRGLLPNPKAGTVGFNIGEIIREIK
AGRIEFRNDKTGAIHAPVGKASFPPEKLADNIRAFIRALEAHKPEGAKGT
FLRSVYVTTVMGPSVRINPHS

Ligand information

• Ligand ID: GLY
• InChI: InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
• InChIKey: DHMQDGOQFOQNFH-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C(=O)O)N
  CACTVS 3.341: NCC(O)=O
  ACDLabs 10.04: O=C(O)CN
• Formula: C2 H5 N O2
• Name: GLYCINE
• ChEMBL: CHEMBL773
• DrugBank: DB00145
• ZINC: ZINC000004658552
• PDB chain: 4reo Chain A Residue 308

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4reo Protein-RNA affinity of ribosomal protein L1 mutants does not correlate with the number of intermolecular interactions.
• Resolution: 1.35 Å
• Binding residue (original residue number in PDB): T34 A35
• Binding residue (residue number reindexed from 1): T27 A28
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation
• GO:0006417 regulation of translation

Cellular Component

• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4reo, PDBe:4reo, PDBj:4reo
• PDBsum: 4reo
• PubMed: 25664749
• UniProt: P27150|RL1_THETH Large ribosomal subunit protein uL1 (Gene Name=rplA)