Structure of PDB 4qzc Chain A Binding Site BS02

Receptor Information
>4qzc Chain A (length=351) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVKKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRAS
SVLKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDER
YKSFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLY
YEDLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVD
FLITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILESTFEKFDLDHFQK
CALILKLDHGRVHQEGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERD
LRRYATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERN
A
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4qzc Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		L189 R193 R454 R458 R461 R462 T465 H466
Binding residue
(residue number reindexed from 1)		L44 R48 R295 R299 R302 R303 T306 H307
Enzymatic activity
Catalytic site (original residue number in PDB) D343 D345 D434
Catalytic site (residue number reindexed from 1) D198 D200 D275
Enzyme Commision number 2.7.7.31: DNA nucleotidylexotransferase.
3.1.11.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4qzc, PDBe:4qzc, PDBj:4qzc
PDBsum4qzc
PubMed25762590
UniProtP09838|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)

[Back to BioLiP]