Structure of PDB 4qyz Chain A Binding Site BS02

Receptor Information
>4qyz Chain A (length=468) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLLIDNWIPVRPRNGGKVQIINLQSLYCSRDQWRLSLPRDDMELAALAL
LVCIGQIIAPAKDDVEFRHRIMNPLTEDEFQQLIAPWIDMFYLNHAEHPF
MQTKGVKANDVTPMEKLLAEALCGGCTAIALFNQANQAPGFGGGFKSGLR
GGTPVTTFVRGIDLRSTVLLNVLTLPRLQKQFPNESHTENQPTWIKPIKS
NESIPASSIGFVRGLFWQPAHIELCDPIGIGKCSCCGQESNLRYTGFLKE
KFTFTVNGLWPHPHSPCLVTVKKGEVEEKFLAFTTSAPSWTQISRVVVDK
INGNRVAAVVNQFRNIAPQSPLELIMGGYRLERRHDVLMFNQGWQQYGNV
INEIVTVGLGYKTALRKALYTFAEGFKNKDFKGAGVSVHETAERHFYRQS
ELLIPDVLANVNFSQADEVIADLRDKLHQLCEMLFNQSVAPYAHHPKLIS
TLALARATLYKHLRELKP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4qyz Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4qyz Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target.
Resolution3.0303 Å
Binding residue
(original residue number in PDB)		C140 C143 C250 C253
Binding residue
(residue number reindexed from 1)		C123 C126 C233 C236
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0051607 defense response to virus
GO:0099048 CRISPR-cas system
Cellular Component
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qyz, PDBe:4qyz, PDBj:4qyz
PDBsum4qyz
PubMed25123481
UniProtQ46901|CSE1_ECOLI CRISPR system Cascade subunit CasA (Gene Name=casA)

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