Structure of PDB 4qx7 Chain A Binding Site BS02

Receptor Information
>4qx7 Chain A (length=329) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain4qx7 Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4qx7 A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Resolution2.34 Å
Binding residue
(original residue number in PDB)		I144 T209 H212 Y222 K229 H284 V286
Binding residue
(residue number reindexed from 1)		I109 T174 H177 Y187 K194 H249 V251
Annotation score5
Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
External links
PDB RCSB:4qx7, PDBe:4qx7, PDBj:4qx7
PDBsum4qx7
PubMed25128496
UniProtP59997|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)

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