Structure of PDB 4quh Chain A Binding Site BS02
Receptor Information
>4quh Chain A (length=233) Species:
9606
(Homo sapiens) [
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DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKY
EVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGP
VDLKKIGNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETHKIPVEADF
LYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKV
ATEFESFSFDATFHAKKQIPCIVSMLTKELYFY
Ligand information
>4quh Chain J (length=4) [
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DEVD
Receptor-Ligand Complex Structure
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PDB
4quh
Modifying caspase-3 activity by altering allosteric networks.
Resolution
1.759 Å
Binding residue
(original residue number in PDB)
R64 H121 C163 Y204 S205 W206 R207 N208 S209 S249
Binding residue
(residue number reindexed from 1)
R31 H88 C130 Y161 S162 W163 R164 N165 S166 S206
Enzymatic activity
Catalytic site (original residue number in PDB)
T62 S63 H121 G122 C163 R164
Catalytic site (residue number reindexed from 1)
T29 S30 H88 G89 C130 R131
Enzyme Commision number
3.4.22.56
: caspase-3.
Gene Ontology
Molecular Function
GO:0002020
protease binding
GO:0004175
endopeptidase activity
GO:0004190
aspartic-type endopeptidase activity
GO:0004197
cysteine-type endopeptidase activity
GO:0004861
cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005123
death receptor binding
GO:0005515
protein binding
GO:0008047
enzyme activator activity
GO:0008233
peptidase activity
GO:0008234
cysteine-type peptidase activity
GO:0016005
phospholipase A2 activator activity
GO:0044877
protein-containing complex binding
GO:0097153
cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199
cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097200
cysteine-type endopeptidase activity involved in execution phase of apoptosis
Biological Process
GO:0001554
luteolysis
GO:0001666
response to hypoxia
GO:0001782
B cell homeostasis
GO:0001818
negative regulation of cytokine production
GO:0006508
proteolysis
GO:0006915
apoptotic process
GO:0006974
DNA damage response
GO:0007413
axonal fasciculation
GO:0007507
heart development
GO:0007605
sensory perception of sound
GO:0007611
learning or memory
GO:0008627
intrinsic apoptotic signaling pathway in response to osmotic stress
GO:0009410
response to xenobiotic stimulus
GO:0009411
response to UV
GO:0009611
response to wounding
GO:0009749
response to glucose
GO:0010038
response to metal ion
GO:0010165
response to X-ray
GO:0014070
response to organic cyclic compound
GO:0016241
regulation of macroautophagy
GO:0016485
protein processing
GO:0021766
hippocampus development
GO:0030163
protein catabolic process
GO:0030182
neuron differentiation
GO:0030216
keratinocyte differentiation
GO:0030218
erythrocyte differentiation
GO:0030220
platelet formation
GO:0030889
negative regulation of B cell proliferation
GO:0031647
regulation of protein stability
GO:0032025
response to cobalt ion
GO:0032355
response to estradiol
GO:0032496
response to lipopolysaccharide
GO:0034349
glial cell apoptotic process
GO:0034612
response to tumor necrosis factor
GO:0035094
response to nicotine
GO:0035556
intracellular signal transduction
GO:0042542
response to hydrogen peroxide
GO:0043029
T cell homeostasis
GO:0043065
positive regulation of apoptotic process
GO:0043200
response to amino acid
GO:0043525
positive regulation of neuron apoptotic process
GO:0044346
fibroblast apoptotic process
GO:0045165
cell fate commitment
GO:0045786
negative regulation of cell cycle
GO:0046007
negative regulation of activated T cell proliferation
GO:0048011
neurotrophin TRK receptor signaling pathway
GO:0051146
striated muscle cell differentiation
GO:0051384
response to glucocorticoid
GO:0051402
neuron apoptotic process
GO:0051604
protein maturation
GO:0061713
anterior neural tube closure
GO:0070269
pyroptotic inflammatory response
GO:0071407
cellular response to organic cyclic compound
GO:0071887
leukocyte apoptotic process
GO:0072734
cellular response to staurosporine
GO:0097190
apoptotic signaling pathway
GO:0097193
intrinsic apoptotic signaling pathway
GO:0097194
execution phase of apoptosis
GO:0098693
regulation of synaptic vesicle cycle
GO:0140639
positive regulation of pyroptotic inflammatory response
GO:1902004
positive regulation of amyloid-beta formation
GO:1904019
epithelial cell apoptotic process
Cellular Component
GO:0005634
nucleus
GO:0005654
nucleoplasm
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0014069
postsynaptic density
GO:0031264
death-inducing signaling complex
GO:0043025
neuronal cell body
GO:0098978
glutamatergic synapse
View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:4quh
,
PDBe:4quh
,
PDBj:4quh
PDBsum
4quh
PubMed
25343534
UniProt
P42574
|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)
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