Structure of PDB 4qqx Chain A Binding Site BS02

Receptor Information
>4qqx Chain A (length=903) Species: 269800 (Thermobifida fusca YX) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYLSPGLRDTIAS
SMETDEEHAGHCIAFWAGLHDIGKLTREFQQQIAIDLSAYPGEELSGEQR
SHAAATGKWLPFALPSLGYPNGGLVTGLVAQMLGGHHGTFHPHPSFQSRN
PLAEFGFSSPHWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL
ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPSLLDAAGLRPI
TVPPATFTESFPHLSKPNGLQASLAKHLPCLCTGPGLVLITAPMGEGKTE
AAYHVADLLGKATGRPGRFLALPTMATADQMHTRLKEYARYRVENTDLPR
SSTLALLHSMAWLNPDYAPAHRDPFAATDWLMGRKRGLLAPWAVGTIDQA
LMAVLRAKHNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLRWLGTLDV
PVVLLSATLHHSIANSLVKAYLEGARGRRWNRSEPQPVSEVSYPGWLHVD
ARIGKVTRSSDVDPLPIATTPRKPLEVRLVDVPVKEGALNRSTVLAKELT
PLVKQGGCAAIICTTVAEAQGVYDLLSQWFATLAPDLYLLHSRFPNRQRT
EITATIVDLFGKEGAQSGRRPTAVLVATQVVEQSLDLDVDLMISDLAPVS
LLLQRAGRCWRHEHLGIINRPQWAKQPELVVLTPEQNRAPWFPRSWTSVY
PLALLQRTYTLLRRRNGAPVQIPEDVQQLVDDVYDDDSLAEDLEADMERM
GEELAQRGLARNAVIPDPDDAEDNLNGLTEFSFHVLATRFGAGSVRVLCY
YVDTAGNRWLDPECTVEFPEQGTGREGRFTMADCRDLVARTIPVRMGPWA
SQLTEDNHPPEAWRESFYLRDLVLIPQRVTDAVLPTETGGREWLLDPCKG
LIF
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain4qqx Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4qqx Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Resolution3.34 Å
Binding residue
(original residue number in PDB)		D84 H115 H149 H150
Binding residue
(residue number reindexed from 1)		D71 H102 H136 H137
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0051607 defense response to virus
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qqx, PDBe:4qqx, PDBj:4qqx
PDBsum4qqx
PubMed25132177
UniProtQ47PJ0

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