Structure of PDB 4qpx Chain A Binding Site BS02

Receptor Information
>4qpx Chain A (length=495) Species: 11983 (Norwalk virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKGTYCGAPILGPGSAPKLSTKTKFWRSSTAPLPPGTYEPAYLGGKDPRV
KGGPSLQQVMRDQLKPFTEPRGKPPKPSVLEAAKKTIINVLEQTIDPPDK
WSFAQACASLDKTTSSGHPHHMRKNDCWNGESFTGKLADQASKANLMFEE
GKNMTPVYTGALKDELVKTDKIYGKIKKRLLWGSDLATMIRCARAFGGLM
DELKTHCVTLPIRVGMNMNEDGPIIFERHSRYRYHYDADYSRWDSTQQRA
VLAAALEIMVKFSSEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVP
CTSQWNSIAHWLLTLCALSEVTNLSPDIIQANSLFSFYGDDEIVSTDIKL
DPEKLTAKLKEYGLKPTRPDKTEGPLVISEDLNGLTFLRRTVTRDPAGWF
GKLEQSSILRQMYWTRGPNHEDPSETMIPHSQRPIQLMSLLGEAALHGPA
FYSKISKLVIAELYVPRQEPMFRWMRFSDLSTWEGDRNLAPSFVN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4qpx Structure of a backtracked state reveals conformational changes similar to the state following nucleotide incorporation in human norovirus polymerase.
Resolution1.86 Å
Binding residue
(original residue number in PDB)		S23 K25 T117 S118 K127 A164 D167 L184 G186 M192 K207 G218 N220 G301 P303 Y341 N422 S502 F503
Binding residue
(residue number reindexed from 1)		S20 K22 T114 S115 K124 A161 D164 L181 G183 M189 K204 G215 N217 G298 P300 Y338 N419 S492 F493
Enzymatic activity
Enzyme Commision number 3.4.22.66: calicivirin.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4qpx, PDBe:4qpx, PDBj:4qpx
PDBsum4qpx
PubMed25478829
UniProtQ70ET3

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